Dog Owners

How PROZINC Helps

How PROZINC Helps PAGES

For a dog with diabetes, maintaining healthy blood glucose levels can be tricky. 

Fortunately, following injection, PROZINC® (protamine zinc recombinant human insulin) works to safely maintain a dog’s blood glucose levels throughout the day, allowing for convenient once daily dosing for most dogs.1

PROZINC provides fast, effective results for dogs with diabetes.2 With PROZINC’s proven safety profile, it’s the at-home canine diabetes treatment you can feel confident about.

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Important

As with any prescription medication, PROZINC should only be given in the dosage and frequency prescribed by your veterinarian. Talk to your vet before making any adjustments to your dog’s treatment.

Administering PROZINC

If your dog has been diagnosed with diabetes, the idea of administering a daily insulin injection may seem overwhelming.

With a little bit of patience and practice, managing canine diabetes with PROZINC can become a routine part of your day. Here's how it works:

Keep a consistent schedule to help ensure proper treatment.

PROZINC injections should be given before or just after a meal. In multi-dog households, it is important to monitor the diabetic dog to ensure it has eaten a full meal.

Give injections at same time every day.

PROZINC Mode of Action
8:02
Your Dog Has Diabetes: Now What?
3:22
Canine Diabetes: Fact or Fiction?
3:43
Understanding Insulin
3:40
Preparing an Insulin Injection
3:12

Important User Safety Information: For use in dogs and cats only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

Giving Your Dog an Insulin Injection
2:53

Important User Safety Information: For use in dogs and cats only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

Diabetes Regulation & Dogs
2:04

Human Safety Information

For use in cats and dogs only. Keep out of reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

PROZINC Safety & Dosing

Confidence meets convenience with PROZINC, the FDA-approved insulin that provides reliable results for both cats and dogs. 

In a clinical study of 276 diabetic dogs, most dogs treated with PROZINC showed improvement by day 84.1

83.3% showed improvement in excessive thirst.

83.8% showed improvement in excessive urination.

PROZINC uses U-40 syringes to deliver precise, accurate doses, reducing the risk of under- or overdosing.3

Possible Side Effects of PROZINC

The most common adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures, shaking (dogs only), diarrhea, and ataxia. Many of the adverse reactions, such as lethargy, seizures, shaking (dogs only), and ataxia, are associated with hypoglycemia. For more information, please see full prescribing information. 

Canine Safety Information

  • PROZINC is for use in dogs only. Keep out of the reach of children. 
  • Owners should be advised to observe for signs of hypoglycemia (low blood sugar). Signs may include weakness, depression, behavioral changes, muscle twitching, and anxiety. In severe cases of hypoglycemia, seizures and coma can occur. Hypoglycemia can be fatal if an affected animal does not receive prompt treatment. 
  • PROZINC should not be used during episodes of hypoglycemia (low blood sugar).
  • Appropriate veterinary monitoring of blood glucose, adjustment of insulin dose and regimen as needed, and stabilization of diet and activity help minimize the risk of hypoglycemic episodes. The attending veterinarian should evaluate other adverse reactions on a case-by-case basis to determine if an adjustment in therapy is appropriate, or if alternative therapy should be considered.
  • The safety and effectiveness of PROZINC in puppies, or breeding, pregnant, and lactating animals has not been evaluated.

1 PROZINC®(protamine zinc recombinant human insulin) [Freedom of Information Summary]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc; 2019.

2 Ward CR, Christiansen K, Li J, et al. Field efficacy and safety of protamine zinc recombinant human insulin in 276 dogs with diabetes mellitus. Dom Anim Endocrin. 2021;75.

3 Borin-Crivellenti S, Bonagura JD, Gilor C. Comparison of precision and accuracy of U100 and U40 insulin syringes. 2014 ACVIM Forum Research Abstracts Program. J Vet Intern Med. 2014;28:1029

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IMPORTANT SAFETY INFORMATION: PROZINC® (protamine zinc recombinant human insulin) is for use in dogs and cats only. Keep out of the reach of children. Owners should be advised to observe for signs of hypoglycemia (low blood sugar). Signs may include weakness, depression, behavioral changes, muscle twitching, and anxiety. In severe cases of hypoglycemia, seizures and coma can occur. Hypoglycemia can be fatal if an affected animal does not receive prompt treatment. PROZINC should not be used during episodes of hypoglycemia (low blood sugar). Appropriate veterinary monitoring of blood glucose, adjustment of insulin dose and regimen as needed, and stabilization of diet and activity help minimize the risk of hypoglycemic episodes. The attending veterinarian should evaluate other adverse reactions on a case-by-case basis to determine if an adjustment in therapy is appropriate, or if alternative therapy should be considered. The safety and effectiveness of PROZINC in puppies, kittens, or breeding, pregnant, and lactating animals has not been evaluated. For more information, see full prescribing information.