Veterinary Professionals

Frequently Asked Questions

Get answers to many of the questions veterinary professionals have about PROZINC® (protamine zinc recombinant human insulin) and treating diabetes in pets.  

Looking for more information? Check out our free clinic resources. To access educational resources for your clinic, click here.

PROZINC in Cats

PROZINC is a sterile aqueous suspension protamine zinc of recombinant human insulin indicated for the reduction of hyperglycemia and associated clinical symptoms or signs in cats with diabetes mellitus.1

It is the only insulin that is both FDA-approved and recommended by the American Animal Hospital Association (AAHA) for diabetic cats.

PROZINC, like other insulin, helps regulate cellular metabolism, in part by facilitating glucose uptake into cells of the heart, bone and fat tissue, and helping these cells and other cells in the body use glucose for energy.2

Visit our How PROZINC Helps page to learn more.

PROZINC is the first and only insulin that is both FDA-approved and recommended by the American Animal Hospital Association (AAHA) for diabetic cats. PROZINC is designed for cats and backed by the largest safety and efficacy study to date.3

Learn More about PROZINC and how it works to treat feline diabetes and canine diabetes.

PROZINC should be mixed by gently rolling the vial before withdrawing the dose prescribed by your veterinarian from the vial. Using a U-40 syringe, administer the injection under the skin along the back of the neck or on the side of the cat.1 

 

NOTE: It is important that you roll the vial and not shake it. Shaking the vial may reduce the effect of the insulin by breaking the insulin molecules apart.

 

Watch our step-by-step videos on administering PROZINC to cats.

PROZINC is supplied as a sterile injectable suspension in 10-mL and 20-mL multidose vials. Each mL of PROZINC product contains 40 IU (international units) of recombinant human insulin.

Store in an upright position in the refrigerator at 36-46 degrees F (2-8 degrees C). Do not freeze it and protect it from light.1

PROZINC is a suspension and once mixed has a whitish cloudy appearance. If discoloration or other abnormal appearances are observed, indicating contamination within the vial, it should be discarded. Loss of insulin activity in the bottle should always be considered whenever clinical signs recur, regardless of the amount of insulin in the bottle.4

PROZINC carries a two-year shelf life from the date of manufacture.4 Use the 10 mL vial within 60 days of first puncture. Use the 20 mL vial within 80 days of first puncture.

Use of a syringe other than a U-40 syringe may result in incorrect dosing. Read our Safety and Dosing information to learn more.

Veterinarians and veterinary professionals are encouraged to call Boehringer Ingelheim Veterinary Technical Support Team (VeTS) at 1-866-638-2226 for product inquiries. 

 

To report a suspected adverse reaction to PROZINC, please call 1-866-638-2226.

The safety and effectiveness of PROZINC insulin in kittens and in breeding, pregnant and lactating cats has not been evaluated.

Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

PROZINC in Dogs

PROZINC is a sterile aqueous suspension protamine zinc of recombinant human insulin indicated for the reduction of hyperglycemia and associated clinical signs in dogs with diabetes mellitus.6 It is the only recombinant human insulin that is FDA-approved for use in diabetic dogs. 

PROZINC, like other insulin, helps regulate cellular metabolism, in part by facilitating glucose uptake into cells of the heart, bone and fat tissue, and helping these cells and other cells in the body use glucose for energy.2

Visit our How PROZINC Helps page to learn more.

PROZINC is the first and only recombinant human insulin that is FDA-approved for diabetic dogs. PROZINC’s unique pharmacokinetics and extended duration of action make it different from other insulin products. PROZINC’s biphasic curve means most diabetic dogs experience reliable, 24-hour glucose control from a single daily injection.  

Also, dogs receiving PROZINC insulin can be expected to have a lower blood glucose level at the time of once-daily injection instead of a high blood glucose usually recorded with other types of insulin. Clinicians should remember this distinction when checking blood glucose readings or performing blood glucose curves on dogs receiving PROZINC. 

Learn More about PROZINC and how it works to treat canine diabetes.

PROZINC should be mixed by gently rolling the vial before withdrawing the dose. Using a U-40 syringe, injections are administered subcutaneously along the back of the neck or on the side of the dog.6 

It may take up to 42 days for dogs to experience good glycemic control after starting PROZINC. A baseline fructosamine level may be useful when starting PROZINC, for comparison later during treatment. 

Good glycemic control should be based primarily on improved clinical signs (polyuria, polydipsia, polyphagia), maintaining or gaining weight, and the absence of clinical signs of hypoglycemia.  

Initial reassessments can be performed weekly, and clinical response based on the above parameters. Blood glucose curves are not generally required during stabilization on PROZINC. Fructosamine levels can be checked after three weeks on the same PROZINC dose, and then every second week until good control is achieved. 

Learn more about monitoring dogs receiving PROZINC.

PROZINC is supplied as a sterile injectable suspension in 10-mL and 20-mL multidose vials. Each mL of PROZINC product contains 40 IU (international units) of recombinant human insulin.

PROZINC should be stored in an upright position under refrigeration at 36-46°F (2-8°C). Do not freeze. Protect from light.

PROZINC is a suspension and once mixed has a whitish cloudy appearance. If discoloration or other abnormal appearances are observed, indicating contamination within the vial, it should be discarded. Loss of insulin activity in the bottle should always be considered whenever clinical signs recur, regardless of the amount of insulin in the bottle.4

PROZINC carries a two-year shelf life from the date of manufacture.6 Use the 10 mL vial within 60 days of first puncture. Use the 20 mL vial within 80 days of first puncture.

Use of a syringe other than a U-40 syringe may result in incorrect dosing. Read our Safety and Dosing information to learn more.

Veterinarians and veterinary professionals are encouraged to call Boehringer Ingelheim Veterinary Technical Support Team (VeTS) at 1-866-638-2226 for product inquiries. 

To report a suspected adverse reaction to PROZINC, please call 1-866-638-2226.

The safety and effectiveness of PROZINC insulin in puppies and in breeding, pregnant and lactating dogs has not been evaluated.6

Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals.

IMPORTANT USER SAFETY INFORMATION: For use in dogs and cats only. Keep out of the reach of children. Avoid contact with eyes. In case of contact, immediately flush eyes with running water for at least 15 minutes. Accidental injection may cause hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to product may induce a local or systemic allergic reaction in sensitized individuals

1 PROZINC® (protamine zinc recombinant human insulin) cat product insert.

2 Plumb DC. Plumb’s Veterinary Drug Handbook. 5th ed. Hoboken, NJ: Wiley-Blackwell;   2005:412-418.

3 Nelson RW. Disorders of the Endocrine Pancreas. In: Nelson RW, Couto CG, eds. Small Animal Internal Medicine. 4th ed. St. Louis, MO: Mosby Elsevier; 2008:764-802.

4 PROZINC® (protamine zinc recombinant human insulin) [Freedom of Information Summary]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc; 2019.  

5 Ettinger SJ, Feldman EC. Textbook of Veterinary Internal Medicine. 6th ed. Vol 2. Philadelphia, PA: WB Saunders; 2004:1576-1577.

6 PROZINC® (protamine zinc recombinant human insulin) dog product insert.