Veterinary Professionals

PROZINC in Cats

For cats with diabetes, maintaining healthy blood glucose levels can be tricky.

Fortunately, following injection, PROZINC® (protamine zinc recombinant human insulin) provides the appropriate duration of action to help cats maintain stable blood glucose levels with just two daily doses.1

Safety & Efficacy

PROZINC is backed by the largest prospective study in diabetic cats to date.

In this study, PROZINC was proven to improve the clinical signs associated with diabetes in as few as 45 days.2

76% showed improvement in excessive thirst2

74% showed improvement in excessive urination2

89% were considered to be in good body condition3

Another study found that PROZINC and glargine4:

PROZINC's rapid efficacy promotes conditions that favor remission5

In a year-long, randomized trial comparing PROZINC and Glargine in recently-diagnosed diabetic cats, remission rates were not significantly different between groups6

Plus, PROZINC uses U-40 syringes to facilitate more precise measurements of small doses required to treat cats, reducing the risk of under- or overdosing.5

Cats presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized.

The safety and effectiveness of PROZINC insulin in kittens and in breeding, pregnant and lactating cats has not been evaluated.

Possible Side Effects of PROZINC

PROZINC insulin, like other drugs, may cause some side effects. Serious side effects can occur with or without warning.  Possible side effects include low blood glucose (hypoglycemia), insulin antagonism/resistance, rapid insulin metabolism, insulin-induced hyperglycemia (Somogyi effect) and local or systemic reactions.

The most common insulin-related side effect is hypoglycemia. Hypoglycemia can be fatal without prompt treatment.   Download full product information

1 Nelson RW, Henley K, Cole C, et al. Field safety and efficacy of protamine zinc recombinant human insulin for treatment of diabetes melitus in cats. J Vet Intern Med. 2009;23:797-802.

2 FOI for NADA 141-297. (PROZINC) 

3 PROZINC® (protamine zinc recombinant human insulin) cat product insert.  

4 Gostelow R, Scudder C, et al. One-year prospective randomized trial comparing efficacy of glargine and protamine zinc insulin in diabetic cats. J Vet Intern Med. 2017;31(4):1225–1361.

5 Borin-Crivellenti S, Bonagura JD, Gilor C. Comparison of precision and accuracy of U100 and U40 insulin syringes. 2014 ACVIM Forum Research Abstracts Program. J Vet Intern Med. 2014;28:1029.

6 Gostelow R, Scudder C, et al. One-year prospective randomized trial comparing efficacy of glargine and protamine zinc insulin in diabetic cats. Abstract format., ACVIM Proceedings, June 2017.