Veterinary Professionals
PROZINC in Cats
For cats with diabetes, maintaining healthy blood glucose levels can be tricky.
Fortunately, following injection, PROZINC® (protamine zinc recombinant human insulin) provides the appropriate duration of action to help cats maintain stable blood glucose levels with just two daily doses.1
Safety & Efficacy
PROZINC is backed by the largest prospective study in diabetic cats to date.
In this study, PROZINC was proven to improve the clinical signs associated with diabetes in as few as 45 days.2
76% showed improvement in excessive thirst2
74% showed improvement in excessive urination2
89% were considered to be in good body condition3
Another study found that PROZINC and glargine4:
PROZINC's rapid efficacy promotes conditions that favor remission5
In a year-long, randomized trial comparing PROZINC and Glargine in recently-diagnosed diabetic cats, remission rates were not significantly different between groups6
Plus, PROZINC uses U-40 syringes to facilitate more precise measurements of small doses required to treat cats, reducing the risk of under- or overdosing.5
Cats presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized.
The safety and effectiveness of PROZINC insulin in kittens and in breeding, pregnant and lactating cats has not been evaluated.
1 Nelson RW, Henley K, Cole C, et al. Field safety and efficacy of protamine zinc recombinant human insulin for treatment of diabetes melitus in cats. J Vet Intern Med. 2009;23:797-802.
2 FOI for NADA 141-297. (PROZINC)
3 PROZINC® (protamine zinc recombinant human insulin) cat product insert.
4 Gostelow R, Scudder C, et al. One-year prospective randomized trial comparing efficacy of glargine and protamine zinc insulin in diabetic cats. J Vet Intern Med. 2017;31(4):1225–1361.
5 Borin-Crivellenti S, Bonagura JD, Gilor C. Comparison of precision and accuracy of U100 and U40 insulin syringes. 2014 ACVIM Forum Research Abstracts Program. J Vet Intern Med. 2014;28:1029.
6 Gostelow R, Scudder C, et al. One-year prospective randomized trial comparing efficacy of glargine and protamine zinc insulin in diabetic cats. Abstract format., ACVIM Proceedings, June 2017.
STOCK YOUR CLINIC
Please call the Boehringer Ingelheim Animal Health USA Inc. (BI AH USA) Veterinary Technical Solutions Team at 1-888-637-4251 or contact your BI AH USA Representative.
IMPORTANT SAFETY INFORMATION: PROZINC® (protamine zinc recombinant human insulin) is for use in dogs and cats only. Keep out of the reach of children. Owners should be advised to observe for signs of hypoglycemia (low blood sugar). Signs may include weakness, depression, behavioral changes, muscle twitching, and anxiety. In severe cases of hypoglycemia, seizures and coma can occur. Hypoglycemia can be fatal if an affected animal does not receive prompt treatment. PROZINC should not be used during episodes of hypoglycemia (low blood sugar). Appropriate veterinary monitoring of blood glucose, adjustment of insulin dose and regimen as needed, and stabilization of diet and activity help minimize the risk of hypoglycemic episodes. The attending veterinarian should evaluate other adverse reactions on a case-by-case basis to determine if an adjustment in therapy is appropriate, or if alternative therapy should be considered. The safety and effectiveness of PROZINC in puppies, kittens, or breeding, pregnant, and lactating animals has not been evaluated. For more information, see full prescribing information.