Veterinary Professionals

PROZINC in Dogs

PROZINC in Dogs PAGES

Once-daily dosing can be a reality for the majority of your canine diabetic patients with PROZINC® (protamine zinc recombinant human insulin).1

Following injection, PROZINC works to safely maintain glycemic control all day with convenient, once-daily dosing for most of your canine patients.

Safety & Efficacy

PROZINC for dogs is backed by the largest U.S. canine diabetes study to date.

In this study that included over 200 diabetic patients, PROZINC demonstrated efficacy and control of clinical signs associated with diabetes mellitus in both naive and previously treated diabetic dogs.2

83.3% showed improvement in excessive thirst3

83.8% showed improvement in excessive urination3

72% achieved diabetic control2

The safety and effectiveness of PROZINC insulin in puppies and in breeding, pregnant and lactating dogs has not been evaluated.

Possible Side Effects of PROZINC

The most common adverse reactions were lethargy, anorexia, hypoglycemia, vomiting, seizures, shaking (dogs only), diarrhea, and ataxia. Many of the adverse reactions, such as lethargy, seizures, shaking (dogs only), and ataxia, are associated with hypoglycemia. Glucocorticoid and progestogen use should be avoided.

PROZINC is contraindicated during episodes of hypoglycemia and in animals sensitive to protamine zinc recombinant human insulin or any other ingredients in PROZINC. For more information, please see full prescribing information.

1 PROZINC®(protamine zinc recombinant human insulin) [Freedom of Information Summary]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc; 2019.  

2 Ward CR, Christiansen K, Li J, et al. Field efficacy and safety of protamine zinc recombinant human insulin in 276 dogs with diabetes mellitus. Dom Anim Endocrin. 2021;75.

3 European Medicines Agency. CVMP assessment report for type II variation for ProZinc. (EMEA/V/C/002634/II/0015). Amsterdam, The Netherlands; 21 March 2019.

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IMPORTANT SAFETY INFORMATION: PROZINC is for use in dogs and cats only. Keep out of the reach of children. Owners should be advised to observe for signs of hypoglycemia (low blood sugar). Signs may include weakness, depression, behavioral changes, muscle twitching, and anxiety. In severe cases of hypoglycemia, seizures and coma can occur. Hypoglycemia can be fatal if an affected animal does not receive prompt treatment. PROZINC should not be used during episodes of hypoglycemia (low blood sugar). Appropriate veterinary monitoring of blood glucose, adjustment of insulin dose and regimen as needed, and stabilization of diet and activity help minimize the risk of hypoglycemic episodes. The attending veterinarian should evaluate other adverse reactions on a case-by-case basis to determine if an adjustment in therapy is appropriate, or if alternative therapy should be considered. The safety and effectiveness of PROZINC in puppies, kittens, or breeding, pregnant, and lactating animals has not been evaluated. For more information, see full prescribing information.